EFFECT OF OSTEOCYTE-LACUNAE SHAPE AND DIRECTION ON THE FLUID FLOW BEHAVIOR IN OSTEON

Yu Weilun; Wu Xiaogang; Li Chaoxin; Sun Yuqin; Zhang Meizhen; Chen Weiyi

doi:10.6052/0459-1879-19-357

Volume 52 Issue 3

Jun. 2020

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Chinese Journal of Theoretical and Applied Mechanics > 2020 > 52(3): 843-853. > DOI: 10.6052/0459-1879-19-357 CSTR: 32045.14.0459-1879-19-357

Yu Weilun, Wu Xiaogang, Li Chaoxin, Sun Yuqin, Zhang Meizhen, Chen Weiyi. EFFECT OF OSTEOCYTE-LACUNAE SHAPE AND DIRECTION ON THE FLUID FLOW BEHAVIOR IN OSTEON[J]. Chinese Journal of Theoretical and Applied Mechanics, 2020, 52(3): 843-853. DOI: 10.6052/0459-1879-19-357

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EFFECT OF OSTEOCYTE-LACUNAE SHAPE AND DIRECTION ON THE FLUID FLOW BEHAVIOR IN OSTEON

^*College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China
^†College of Physical Education,Taiyuan University of Technology,Taiyuan 030024,China

Received Date: December 17, 2019

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Abstract

Abstract

In order to accurately describe the fluid flow in osteon, this study developed a method to describe the fluid anisotropic flow based on the density, shape and direction of lacunae. Firstly, the number and distribution of the bone canaliculi around the lacunae were calculated. Secondly, the permeability and porosity were estimated by using the calculated parameters and other microstructure data of bone tissue. Finally, the poroelastic finite element model of osteon was established according to the calculated parameters, and the influence of lacunae shape and direction on the fluid flow behavior in osteon under the axial displacement load was analyzed. The results showed that the lacunae shape and direction had a significant effect on the value and distribution of fluid pressure and velocity in osteon. For the range of parameters investigated, the influence of the lacunae shape on the maximum pressure and flow velocity in the same region of different osteon models can reach 86% and 18%, respectively, and the influence of the lacunae direction on that can reach 125% and 56%, respectively. In addition, the lacunae shape and direction had a great influence on the local pressure and velocity of a single osteon (up to 62% difference in fluid pressure between regions due to the influence of the lacunae shape, and up to 58% and 50% difference in fluid pressure and flow velocity due to the influence of the lacunae direction, respectively). The model showed that the lacunae shape and direction and the three-dimensional distribution of the canaliculus can determine the degree of anisotropy fluid flow in osteon. This study help to accurately quantify the anisotropic flow behavior of interstitial fluid of bone.
- lacunae,
- osteocyte,
- poroelastic,
- osteon,
- bone canaliculus,
- permeability

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References

Verbruggen SW, Vaughan TJ, McNamara LM. Fluid flow in the osteocyte mechanical environment: A fluid-structure interaction approach. Biomech Model Mechanobiol, 2014, 13(1): 85-97

Maycas M, Esbrit P, Gortázar AR.Molecular mechanisms in bone mechanotransduction. Histology & Histopathology, 2017, 32(8): 751-760

Middleton K, Kondiboyina A, Borrett M, et al.A Microfluidics Approach to Investigate the Role of Dynamic Similitude in Osteocyte Mechanobiology. Journal of Orthopaedic Research, 2017, 36(2): 663-671

Smalt RG, Mitchell FT, Howard RL, et al.Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain. American Journal of Physiology, 1997, 273(4 Pt 1): E751-758

Wittig NK, Laugesen M, Birkbak ME, et al.Canalicular junctions in the osteocyte Lacuno-Canalicular network of cortical bone. ACS Nano, 2019, 13(6): 6421-6430

Santos A, Bakker AD, Klein-Nulend J.The role of osteocytes in bone mechanotransduction. Osteoporosis International, 2009, 20(6): 1027-1031

Goulet GC, Coombe D, Martinuzzi RJ, et al.Poroelastic evaluation of fluid movement through the lacunocanalicular system. Annals of Biomedical Engineering, 2009, 37(7): 1390-1402

武晓刚, 于纬伦, 王兆伟等. 一种骨小管中液体流动产生的流量及切应力模型. 力学学报, 2016, 48(5): 1208-1216
(Wu Xiaogang, Yu Weilun, Wang Zhaowei, et al.A canalicular fluid flow model associated with its fluid flow rate and fluid shear stress. Chinese Journal of Theoretical and Applied Mechanics, 2016, 48(5): 1208-1216 (in Chinese))

Chen Y, Wang W, Ding S, et al.A multi-layered poroelastic slab model under cyclic loading for a single osteon. Biomedical Engineering Online, 2018, 17(1): 97

Bacabac RG, Mizuno D, Schmidt CF, et al.Round versus flat: Bone cell morphology, elasticity, and mechanosensing. Journal of Biomechanics, 2008, 41(7): 1590-1598

Carter Y, Thomas CDL, Clement JG, et al.Variation in osteocyte lacunar morphology and density in the human femur -- a synchrotron radiation micro-CT study. Bone, 2013, 52(1): 126-132

Yu W, Cen H, Wu X, et al.Finite element study of the effect of osteon morphology variation related ageing, osteoporosis, or physical activity level on its poroelastic behaviors. Journal of Hard Tissue Biology, 2018, 7(4): 333-342

Verbruggen S, Mc Garrigle M, Haugh M, et al.Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis. Biophysical Journal, 2015, 108(7): 1587-1598

Verbruggen SW, Vaughan TJ, McNamara LM. Mechanisms of osteocyte stimulation in osteoporosis. Journal of the Mechanical Behavior of Biomedical Materials, 2016, 62:158-168

Hemmatian H, Bakker AD, Klein-Nulend J, et al.Aging, Osteocytes, and Mechanotransduction. Current Osteoporosis Reports, 2017, 15(5): 1-11

Rolvien T, Schmidt FN, Milovanovic P, et al.Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis. Scientific Reports, 2018, 8(1): 1-11

Beno T, Yoon Y-J, Cowin SC, et al.Estimation of bone permeability using accurate microstructural measurements. Journal of Biomechanics, 2006, 39(13): 2378-2387

Remaggi F, Can?V, Palumbo C, et al. Histomorphometric study on the osteocyte lacuno-canalicular network in animals of different species. I. Woven-fibered and parallel-fibered bones. Italian Journal of Anatomy and Embryology , 1998, 103(4): 145-155

Ferretti M, Muglia MA, Remaggi F, et al.Histomorphometric study on the osteocyte lacuno-canalicular network in animals of different species. II. Parallel-fibered and lamellar bones. Italy Journal of Anat Embryol, 1999, 104(3): 121-131

Ascenzi MG, Gill J, Lomovtsev A.Orientation of collagen at the osteocyte lacunae in human secondary osteons. 2008, 41(16): 3426-3435

Bach-Gansmo F, Weaver J, Jensen M, et al.Osteocyte lacunar properties in rat cortical bone: differences between lamellar and central bone. Journal of Structural Biology, 2015, 191(1): 59-67

Cardoso L, Fritton SP, Gailani G, et al.Advances in assessment of bone porosity, permeability and interstitial fluid flow. Journal of Biomechanics, 2013, 46(2): 253-265

Weinbaum S, Cowin SC, Zeng Y.A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. Journal of Biomechanics, 1994, 27(3): 339-360

You LD, Weinbaum S, Cowin SC, et al.Ultrastructure of the osteocyte process and its pericellular matrix. Anatomical Record Part A Discoveries in Molecular Cellular & Evolutionary Biology, 2004, 278A(2): 505-513

Hannah KM, Thomas CDL, Clement JG, et al.Bimodal distribution of osteocyte lacunar size in the human femoral cortex as revealed by micro-CT. Bone, 2010, 47(5): 866-871

Tommasini SM, Trinward A, Acerbo AS, et al.Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT. Bone, 2012, 50(3): 596-604

Miszkiewicz JJ, Mahoney P.Histomorphometry and cortical robusticity of the adult human femur. Journal of Bone & Mineral Metabolism, 2018, 37(5): 1-15

Benalla M, Palacio-Mancheno PE, Fritton SP, et al.Dynamic permeability of the lacunar-canalicular system in human cortical bone. Biomechanics & Modeling in Mechanobiology, 2013, 13(4): 801-812

Zhang D.Oscillatory pressurization of an animal cell as a poroelastic spherical body. Annals of Biomedical Engineering, 2005, 33(9): 1249-1269

Blott SJ, Pye K.Particle Shape: A review and new methods of characterization and classification. Sedimentology, 2007, 55(1): 31-63

Heveran CM, Rauff A, King KB.A new open-source tool for measuring 3D osteocyte lacunar geometries from confocal laser scanning microscopy reveals age-related changes to lacunar size and shape in cortical mouse bone. Bone, 2018, 110(2018): 115-127

Fanchi RJ.Directional permeability. Spe Reservoir Evaluation & Engineering, 2006, 11(03): 565-568

武晓刚, 王宁宁, 岑海鹏等. 血管脉动对骨单元内液体流动行为的影响. 生物医学工程学杂志, 2017, 34(5): 695-701
(Wu, Xiaogang, Wang Ningning, Cen Haipeng, et al. Effect of artery pulse on the osteonal interstitial fluid flow behavior. Journal of Biomedical Engineering, 2017, 34(5): 695-701 (in Chinese))

Wu X, Zhao T, Wu X, et al.Interstitial fluid flow behavior in osteon wall under non-axisymmetric loading: a finite element study. Journal of Mechanics in Medicine and Biology, 2018, 18(7): 1840007

Wu X, Chen K, Wang Z, et al.An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC). Applied Mathematics and Mechanics(English Edition), 2018, 39(6): 813-828

Nguyen VH, Lemaire TS.Poroelastic behaviour of cortical bone under harmonic axial loading: a finite element study at the osteonal scale. Medical Engineering & Physics, 2010, 32(4): 384-390

Rémond A, Naili S.Transverse isotropic poroelastic osteon model under cyclic loading. Mechanics Research Communications, 2005, 32(6): 645-651

王兆伟, 武晓刚, 陈魁俊等. 一种力-电协同驱动的细胞微流控培养腔理论模型. 力学学报, 2018, 50(1): 124-137
(Wang Zhaowei, Wu Xiaogang, Chen Kuijun, et al.A theoretical microfluidic flow model for the cell culture chamber under the pressure gradient and electric field driven loads. Chinese Journal of Theoretical and Applied Mechani, 2018, 50(1): 2124-2137 (in Chinese))

Zhang DJ, Weinbaum S, Cowin SC.On the calculation of bone pore water pressure due to mechanical loading. Internatural Journal of Solids and Structures, 1998, 35(34-35): 4981-4997

Danielle T, Richard C, N. WM, et al. Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy. Plos One, 2017, 12(10): e0186846

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EFFECT OF OSTEOCYTE-LACUNAE SHAPE AND DIRECTION ON THE FLUID FLOW BEHAVIOR IN OSTEON