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Feng Shiliang, Zhu Weiping. SIMULATION FOR REVERSAL OF CELL POLARITY BASED ON BIDIRECTIONAL TRANSPORT OF SIGNALING MOLECULES[J]. Chinese Journal of Theoretical and Applied Mechanics, 2015, 47(2): 337-345. DOI: 10.6052/0459-1879-14-242
Citation: Feng Shiliang, Zhu Weiping. SIMULATION FOR REVERSAL OF CELL POLARITY BASED ON BIDIRECTIONAL TRANSPORT OF SIGNALING MOLECULES[J]. Chinese Journal of Theoretical and Applied Mechanics, 2015, 47(2): 337-345. DOI: 10.6052/0459-1879-14-242
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SIMULATION FOR REVERSAL OF CELL POLARITY BASED ON BIDIRECTIONAL TRANSPORT OF SIGNALING MOLECULES

  • Shanghai University, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai 200072, China

Funds: The project was supported by the National Natural Science Foundation of China (31370940).
  • Received Date: August 17, 2014
  • Revised Date: October 30, 2014
    Graphical Abstract
    • Abstract
  • To investigate the mechanisms underlying the reversal of cell polarity, a mathematical model consisting of a pair of reaction-di usion equations was presented and solved numerically with the Lattice—Boltzmann method. It was found that, by applying a reversal gradient of Rac signal in a cell, labels for lamellipod (i.e., PI3K, and PIP3) would disappear from the front of cell, and redistribute to the rear, while labels for tail (i.e., PTEN, PIP2) would act oppositely. The spatiotemporal patterns of lamellipod and tail interconversion derived from our numerical simulation agreed well with that of the experimental observations. Besides, the time delay taking place between actin assembly at the new front and disassembly at the previous front was medicated by the completion of an activator (i.e., PI3K), without the help of a supposed "global inhibitor".
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    • References (30)
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