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青光眼发病机理--筛板变形研究进展

张婷 李龙 宋凡

张婷, 李龙, 宋凡. 青光眼发病机理--筛板变形研究进展[J]. 力学学报, 2019, 51(5): 1273-1284. doi: 10.6052/0459-1879-18-321
引用本文: 张婷, 李龙, 宋凡. 青光眼发病机理--筛板变形研究进展[J]. 力学学报, 2019, 51(5): 1273-1284. doi: 10.6052/0459-1879-18-321
Zhang Ting, Li Long, Song Fan. PATHOGENETIC MECHANISMS OF GLAUCOMA------RESEARCH PROCESS ON THE DEFORMATION OF LAMINA CRIBROSA[J]. Chinese Journal of Theoretical and Applied Mechanics, 2019, 51(5): 1273-1284. doi: 10.6052/0459-1879-18-321
Citation: Zhang Ting, Li Long, Song Fan. PATHOGENETIC MECHANISMS OF GLAUCOMA------RESEARCH PROCESS ON THE DEFORMATION OF LAMINA CRIBROSA[J]. Chinese Journal of Theoretical and Applied Mechanics, 2019, 51(5): 1273-1284. doi: 10.6052/0459-1879-18-321

青光眼发病机理--筛板变形研究进展

doi: 10.6052/0459-1879-18-321
基金项目: 1)国家重点研发计划项目(2016YFA0501601);中国科学院战略性先导科技专项(B)类(XDB22040102);国家自然科学基金项目资助.(11472285)
详细信息
    通讯作者:

    宋凡

  • 中图分类号: Q66

PATHOGENETIC MECHANISMS OF GLAUCOMA------RESEARCH PROCESS ON THE DEFORMATION OF LAMINA CRIBROSA

  • 摘要: 青光眼是世界上第一大不可逆致盲眼病.其病变与眼内压直接相关,控制眼内压是目前控制青光眼发展的唯一有效途径,但发病的确切机制尚未明确.现已证实,青光眼的原发部位是巩膜筛板:由筛板前后分别承受的眼内压与颅内压产生的压力差会导致筛板结构与形态发生变化,进而挤压穿过筛板的视觉神经,造成视觉神经损伤,产生不可逆的视觉损失.因此,青光眼的发病机理与筛板的力学特性及其周围的力学环境密切相关.自从筛板被确定为青光眼视神经损害的原发部位,筛板便成为该领域的研究热点.其中,通过建立筛板力学模型,研究眼内压与颅内压作用下筛板的受力变形,进而分析筛板变形对视神经的损伤,有助于揭示青光眼视神经损伤机制及青光眼的发病机理.本文将从相关实验、理论和计算以及临床等方面介绍青光眼发病机理中筛板变形的研究进展以及目前存在的问题.

     

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  • 收稿日期:  2019-09-29
  • 刊出日期:  2019-09-18

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