Abstract: Hyperplasia of atherosclerotic plaque can induce hemodynamic abnormalities due to the geometry of the blood vessels changed. This can lead to serious complications such as stroke and ischemic eye disease. The lack of a deep understanding of early plaque dynamic evolution and its associated mechanisms involved in inflammatory response and lipid metabolism is one of the limitations of existing studies. Therefore, the establishment of a more detailed growth dynamics model is of great significance to enrich our research tools.A set of fluid-structure coupling multi-physical field model integrating early plaque growth dynamics was proposed in this work, which can simultaneously reflect the atherosclerotic plaque growth under the synergistic effect of lipoprotein concentration diffusion and plaque volume expansion, as well as the interactive coupling effect of subintimal deformation and hemodynamic response. In particular, the nonlinear mechanical properties of the atherosclerotic