Abstract: Hypersonic liquid film cooling technology is to press out the cooling medium through a series of slits or holes, creat a low-temperature cooling film in the boundary layer of the surface of the aircraft to prevent the aerodynamic heating of the aircraft by hypersonic airflow. As an active cooling method, it has great application potential in surface thermal protection of hypersonic vehicle. In this paper, numerical methods and VOF model are used to study the spreading of liquid film at 25 km flight altitude and Ma=5 airflow. The evolution process and cooling mechanism of liquid film on a flat plate are discussed through the incident velocity, Angle, surface tension and viscosity coefficient of different cooling medium. The results show that under the action of air flow, the liquid film develops downstream to the wall surface, the existence of the liquid film leads to the boundary layer separation, and the continuous liquid film will be broken into liquid blocks at a certain position, and then further broken into droplets. The change of incident conditions and liquid properties will affect the development of the liquid film along the flow direction, which is manifested in the position of the fracture point and the thickness of the continuous liquid film. Within the computational domain set in this paper, the wall heat flow is reduced by 80% ~ 95%, and the cooling efficiency of the liquid film on the wall varies with the the change of the liquid film morphology.