Abstract: Focusing on the national strategic goal of "Carbon Peaking and Carbon Neutrality", this paper comprehensively analyzes the strategic conditions and targets suitable for large-scale CO₂ geo-storage in the China offshore basins, from the perspectives of fault activity, basin pressure, tectonic subsidence, seismicity, and geothermal gradient. It is considered that the East China Sea Shelf Basin, Pearl River Mouth Basin, eastern Qiongdongnan Basin, and the central South China Sea basin are the best geological storage areas for CO₂, although this does not exclude suitable targets in other unfavorable sedimentary basins since a specific geo-sequestration target is small in area. The suitable CO₂ storage strata in the East China Sea Shelf, Pearl River Mouth, and Qiongdongnan Basins include the bottom salt-water layer of the late rapid subsidence sediments in the open-sea environment and the hydrocarbon-bearing units in the thermal subsidence sedimentary sequences. Between 800 and 4000 m depths beneath the seafloor, the porosity is greater than 10%, and the hydrostatic and lithostatic pressures vary from ~ 8 to ~ 40 MPa and from ~ 13 to ~ 83 MPa, respectively. In this pressure and suitable geothermal gradient ranges, CO₂ exists in a supercritical state, and its density is relatively stable with temperature and pressure changes, which is beneficial to the flow and permeation of CO₂. The scale and number of mafic magmatic rock formations in the basins also provide good conditions for CO₂ geological sequestration and permanent mineralization. Although operationally difficult and expensive, CO₂ storage in the central South China Sea basin is very safe. CO₂ injected deep into the oceanic basalt can undergo basalt mineralization, but if CO₂ is escaped as the mineralization process is relatively slow, escaped CO₂ can be further trapped by multiple other storage processes, including pyroclastic rock mineralization, seafloor sediment sequestration, seabed sediment CO₂ hydrate storage, carbonate neutralization reaction, seabed carbon lake, ocean dissolution, etc. The existing six International Oceanic Discovery Program (IODP) boreholes that have encountered basement basalt in the central basin of the South China Sea can provide a good scientific and engineering foundation for the pilot CO₂ storage experiment in the South China Sea basin.