Abstract: In this paper we investigate the evolution dynamics of side-by-side droplets after being impacted by a planar shock by using a three-dimensional conservative sharp interface method. Our research mainly focuses on the development of wave structures after the shock impact and the asymmetric interface evolution of single droplet induced by the coupling between the side-by-side droplets. Firstly, we analyze the development of the wave system including those inside and outside the channel between the side-by-side droplets. We find that at the early stage of impact, the intersection of reflected shock waves accounts for the formation of new reflected shock waves and Mach rods. This is quite different from the curved wave front formed by the reflected shock wave on the other side of the droplet transversely opposite to the channel. The difference of the flow field on the two sides of the droplet is responsible for the asymmetric interface evolution of the droplet in the middle stage of the droplet-shock interaction. Secondly, we investigate the interface morphology and its evolution in the middle stage of shock impact, especially when the incident shock wave moves to the downstream of and is far away from the droplets, and report the occurrence of new flow phenomena at the downstream outlet of the channel, such as interface coalescence caused by airflow expansion and subsequent interface fragmentation owing to airflow blockage. Finally, the effect of the gap between the side-by-side droplets on the droplet interaction is studied. We find that the gap size has a significant effect on the occurrence of pressure peaks in the channel. Specifically, a smaller gap not only brings higher pressure peak, but also makes the peak appear at an earlier time.