Abstract: Owing to its particular structure and preparationtechnique, the mechanical parameters of intraocular lens are hard to obtainby means of standard methods. A mixed numerical-experimental method is usedto identify the parameters in Mooney-Rivlin constitutive model ofintraocular lens. The result shows that perfect identification precision canbe obtained using Mooney-Rivlin model in certain deformation range ofintraocular lens. Moreover, we simulate the implantation process andoperation state of intraocular lens using finite element numericalsimulation. The method solves the problem of acquiring materials parametersto a large extent, meanwhile, and lays a foundation for wide application offinite element numerical simulation technique in the biomedical field.