Abstract: Mr. Che-Min Cheng had been actively practicing and advocating Mr. Hsue-Shen Tsien’s engineering science thought throughout his life. He himself had also inherited and carried forward engineering science, which is of great practical significance to the promotion of technological innovation in China. Firstly, this paper expounds the definition, methodology and characteristics of engineering science, emphasizing that proposing new solutions is the core content of engineering science and addressing the role of engineering scientists in technological innovation. Secondly, the paper interprets the role of engineering science in technological innovation by analyzing several engineering cases, e.g. the use of explosion methods to deal with underwater foundations, the related techniques in the construction of the Three Gorges coffer. The paper clarifies the theoretical basis and engineering science nature of numerical simulation, in which how to select generalized variables and construct the structure of the solutions is the extremely creative work. The core of the continuous discontinuous simulation method is to construct mutable generalized variables in time domain. Several simulation cases that embody engineering science methodology are listed. The paper also introduces how to systematically practice the methodology of engineering science in the study of key mechanical problems in landslide disaster prevention, expounds the uniqueness of inversion and the feasibility of combining monitoring and numerical simulation, and gives the concept of progressive failure and rupture degree. Finally, based on the cognition of developing high-pressure unloading ore pulverization technology, the paper proposes several engineering scientific research directions for the development of rock physics.