Abstract: Recently emerging multi-principal component high-entropy alloy is expected to replace copper as a new generation of shaped charge liner material due to its wide composition/property control range and a series of excellent mechanical properties. Based on the experiments and numerical simulation of dynamic mechanical properties of five-element CrMnFeCoNi high-entropy alloy, the feasibility of this alloy as a shaped charge liner is explored. The mechanical behavior of high-entropy alloys at different strain rates and temperatures was studied via split Hopkinson tensile bar (SHTB) and material testing machine, and a Johnson-Cook thermal viscoplastic dynamic constitutive model of high-entropy alloys was established. The continuity condition of high-entropy alloy jet is explored based on the relationship between flow velocity and critical collapse angle. The continuity condition of high-entropy alloy jet is verified by finite element simulation, and the evolution law of high-speed tensile fracture of high-entropy alloy jet is further investigated. The results show that the jet break-up time is negatively correlated with the material tensile strength, and when the dynamic tensile strength increases, the jet break-up time will decrease. This work was provide references for the structural design of novel high-entropy alloy linev.