Abstract: In order to achieve the drag reduction effect, the experimental scheme of zero-mass jet active control turbulent boundary layer is designed independently in the paper. Dual piezoelectric (PZT) oscillators as the active control actuators are symmetrically distributed embedded along the spanwise direction of the flat plate in turbulent boundary layer. The experimental investigation is carried out by synchronous (syn) and asynchronous (asyn) vibration active control mode to achieve drag reduction with the periodic vibration of dual PZT oscillators in a wind tunnel. It realizes the periodic interference and modulation to the multi-scale coherent structure in turbulent boundary layer. Furthermore, it reduces the skin friction and realizes drag reduction effect in all controlled cases.The consequence shows that the maximum drag reduction rate of 18.54% is obtained at 100 V, 160 Hz asynchronous vibration case.The multi-scale wavelet analysis of streamwise velocity shows that the energy of the small-scale coherent structure increases while the large-scale coherent structure decreases in all controlled conditions.Meanwhile, it adjusts the energy distribution of the large-scale and small-scale coherent structures in near-wall regions of turbulent boundary layer .The drag reduction effect of the asynchronous controlled case is better than the synchronous controlled case at the same voltage and frequency of vibration. When the vibration frequency of the PZT oscillators is 160 Hz, the PDF curves of the wavelet coefficient show the fluctuation characteristics and the tails of the PDF curve widen significantly. The pulsations of near-wall regions become more ordered and regular and the turbulence weakens intermittently after control in turbulent boundary layer.The results of the conditional phase averaging of small-scale coherent structure show that the periodic perturbations of the PZT oscillators enhance the turbulence intensity of the small-scale coherent structures. Furthermore, drag reduction effect is also achieved by breaking the large-scale coherent structure into the small-scale coherent structure. As the streamwise position is far away from the PZT oscillators, the modulation effect of the coherent structure in turbulent boundary layer gradually weakens.