Abstract: Shock wave and turbulent boundary layer interaction widely exists in the internal and external flow of high-speed aircraft. The aerodynamic performance and flight safety of aircraft are seriously affected by the strong pressure fluctuation in the interaction region. To investigate statistical characteristics of fluctuating pressure, the interaction between an incident shock of 33.2° and a spatially developed Mach 2.25 turbulent boundary layer is analyzed by means of direct numerical simulation (DNS). The numerical results have been carefully validated against with previous experiment and DNS at similar flow conditions in terms of mean velocity profile, turbulence intensity and wall pressure distribution. Statistics at the wall and in the outer layer, including fluctuation intensity, power spectral density, two-point correlation and space-time correlation, are quantitatively compared. The differences between them are analyzed in detail. It is found that the effect of the shock interaction on the wall-pressure fluctuation and the fluctuating pressure in the outer layer are utterly different. Based on the analysis of the power spectra density, the fluctuations in the separated region are both characterized by the low-frequency content, but in the reattachment region, the peak frequency of outer pressure fluctuations quickly shifts to higher frequency, with the low-frequency energy of wall-pressure fluctuation still being predominant. It is identified that the two-point correlations of pressure fluctuation at the wall and in the outer layer are both more elongated in the spanwise direction than that in the streamwise direction. The integral scale at the wall is generally increased, while the one in the outer layer increases sharply after passing the shock and then gradually decreases. The analysis of space-time correlation indicates that the iso-correlation contours are similar to the elliptical distribution and the convection velocity deduced by the correlation is dramatically decreased. Downstream of the interaction, the convection velocity in the outer layer is higher than that of wall-pressure fluctuation.