Abstract: This study presents a method to identify the main parameters(B and K) in bone growth and remodeling equation which is based on the animal Experiment of rapid-growing Rats in Different Stress Environment. The results are proved to be of good stability and identification precision with the numerical method of BFGS by analysis. It suggests that B and K are variables changing with time and space. The research shows that solving the uncertainty and unknown properties of life phenomenon with inversion theory and method is an effective way. The thought and method used in the research of bone growth and remodeling adaptation and quantification of unknown parameters of bone growth equation in this paper also provide clue and reference to establish human model of bone growth and remodeling.