Abstract: As one of the most successful methodologies for turbulence modeling in science and engineering application, large eddy simulation (LES) has become one of the most promising models for the study of turbulent flow and combustion in internal combustion engine (ICE) over the past decade, since it can provide detailed information about the three-dimensional transient turbulent in-cylinder processes with reasonable computing cost. In this paper a review of the current status and new developments of researches on LES applications in ICE is given and most significant results are presented. The basic concept, method and subgrid models of LES are outlined, and the development and achievements of LES, both domestic and international, are described with emphasis on the in-cylinder flow field, fuel injection and atomization as well as the two-phase spray turbulent combustion. Finally, existing problems in the current application of LES in ICE and possible solutions are discussed.