CD44-配体相互作用的生物力学与功能调控1)
BIOMECHANICS AND FUNCTIONAL REGULATIONS OF CD44-LIGAND INTERACTIONS1)
CD44-配体相互作用的生物力学与功能调控1) |
| 李林达, 丁奇寒, 陈深宝, 吕守芹, 龙勉, 郭兴明 |
|
BIOMECHANICS AND FUNCTIONAL REGULATIONS OF CD44-LIGAND INTERACTIONS1) |
| Li Linda, Ding Qihan, Chen Shenbao, Lü Shouqin, Long Mian, Guo Xingming |
| 图1 CD44-配体相互作用的微观结构特征: (a)细胞粘附分子PSGL-1、CD44、E选择素与HA的分布及相互作用网络; (b) PSGL-1的N末端糖基sLe$^{X}$作用在E选择素Lectin结构域的钙离子附近; (c) HA作用导致CD44 HABD结构域发生构象改变 |
| Fig.1 Microstructural features of CD44-ligands interactions: (a) Schematic interaction network among PSGL-1, CD44, E-selectin and HA; (b) conformational allostery of CD44 HABD domain induced by HA binding; (c) crystalized E-selectin-sLe$^{X}$ interaction complex |
|
|