细胞内吞纳米颗粒药物的数值模拟研究

刘心悦, 龚晓波, 黄华雄

A NUMERICAL STUDY ON ENDOCYTOSIS OF NANOPARTICLES

Liu Xinyue, Gong Xiaobo, Huang Huaxiong

Table 1 The physical constants in the model

Physical quantity and symbol Value Bending modulus kb 20kBT [16] Cell membrane thickness h 5 nm [21] Young’s modulus of cell membrane EC 106, 107 Pa [17,22] Density of ligands ρ 500 μm-2 [10] Free length of binding bonds l0 20 nm [23] Drug radius r 12.5, 25, 50 nm [10] Spring strength of binding bonds ks 1,10 pN/nm [12,24] Young's modulus ratio ofdrug and cell membrane α 100 [25]