表皮生长因子影响鼠小肠增量杨氏模量的研究
The incremental Young's moduli in the rat small intestine caused by
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摘要: 研究表皮生长因子(EGF)2,4,7,14d处理后鼠小肠所发生的生物力学重建. 通过双轴试验(膨胀与轴向拉伸组合)，用最小二乘法计算了近于在体状态下环向、纵向及交叉向增量杨氏模量. 各组环向和纵向模量均不相等，即正常状态和EGF处理后的小肠是各向异性的. 在EGF处理期间，各向的杨氏模量随时间变化(P<0.05). 在EGF处理的最初7d中，环向模量减小，在处理14d后，又恢复到对照组的水平. 增量模量介于17.4kPa与24.2kPa之间. 纵向模量的值介于22.9kPa与32.4kPa之间，在处理4d后，比对照值显著增大(P<0.02).交叉模量的值介于4.7kPa与6.6kPa之间，在最初EGF处理的4d中降低，此后增加并于第7d达到最大值. 可以得出结论，肠壁的力学性质呈各向异性且在EGF处理期间会发生重建.
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关键词:
- EGF处理,小肠,杨氏模量,各向异性
Abstract: Biomechanical remodelling of the rat small intestineafter treatment with epidermal growth factor (EGF) subcutaneously for 2 days(n=6), 4 days (n=6), 7 days (n=6), and 14 days (n=4) was studied. Theincremental circumferential, longitudinal and cross moduli close to the invivo state were computed from bi-axial test data (combined inflation andaxial stretching) by a least square method. The moduli in thecircumferential direction and the longitudinal direction differed in allgroups, i.e. the mechanical properties were anisotropic in both normal andEGF-treated rats. Time-dependent variation existed for the Young's moduli inall directions during EGF treatment (P<0.05). The circumferential modulusdecreased during the first 7 days of EGF treatment and it almost remodelledback to that of the control group after 14 days treatment. The incrementalmodulus in the circumferential direction ranged between 17.4kPa and 24.2kPa.The modulus in the longitudinal direction ranged between 22.9kPa and 32.4kPa.The longitudinal modulus after 4 days EGF treatment was significantly largerthan that of control group (P<0.02). The cross modulus decreased during thefirst 4 days of EGF treatment thereafter it increased to a maximum at 7days. The values for the cross moduli were between 4.7kPa and 6.6kPa. Inconclusion, the mechanical properties in the intestinal wall are anisotropicand remodel during treatment with EGF. -
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