Chinese Journal of Theoretical and Applied Mechani ›› 2013, Vol. 45 ›› Issue (6): 974-981.DOI: 10.6052/0459-1879-13-045

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MICRO-SCALE NUMERICAL STUDY OF THE EFFECT OF ERYTHROCYTE MECHANICAL PROPERTIES ON THE NEAR-WALL MOTION OF PLATELET

Xu Jing1, Wang Xiaolong1, Liu Yunqiao1,2, Gong Xiaobo1,2   

  1. 1. Department of Engineering Mechanics, Shanghai Jiao Tong University, Shanghai 200240, China;
    2. MOE Key Laboratory of Hydrodynamics, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2013-02-04 Revised:2013-05-08 Online:2013-11-23 Published:2013-11-25
  • Supported by:

    The project was supported by the National Natural Science Foundation of China (11072155,11232010) and Ph.D. Programs Foundation of Ministry of Education of China (20100073120009).

Abstract:

The effect of erythrocyte mechanical properties on the near-wall motion of platelet was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by a hyper-elastic membrane with negligible thickness. The numerical results show that with the increase in hematocrit, the near-wall approaching is enhanced; platelet exhibits larger deformation and orientation (angle of its near-wall tank-treading motion); the lateral force pushing platelet to the wall is increased with larger fluctuation amplitude of lateral force, while the near-wall approaching is reduced by increasing the stiffness of erythrocytes.

Key words:

hemodynamics|fluid-membrane interaction|the immersed boundary method|near-wall motion of platelet

CLC Number: