Abstract: Direct numerical simulation (DNS) of the interaction of shock wave and shear layer was performed. The compressible unsteady two-dimensional Navier-Stokes equations were solved using the fifth-order WENO scheme combined with the third-order TVD Runge-Kutta scheme. The purpose of this paper is to reveal the mechanism of sound generation in the interaction of shock wave and shear layer. The results show that: (1) When incident shock wave is passing through the shear layer, the center of the vortex cores is shifted towards the lower side; (2) The interaction of incident shock wave and shear layer generates shocklet, and then acoustic wave is generated and radiated at the locus of contact of shocklet and shear layer; (3) Several arc-shocks are formed after reflected shock wave passing through shear layer; (4) When reflected shock wave is passing through shear layer, shock wave is leaking in the braid region and shock-associated noise is generated at the saddle points between vortices. This is a form of shock leakage mechanism.