Abstract: The effects of flexible joints on the dynamic response and control of robot are studied in this paper. Firstly, the spatial robot model consisting of n flexible joints and n flexible links is built, and the dynamic equations of the robot system are derived via the Lagrangian's equations. The tensile deformation, bending deformation, torsional deformation, and nonlinear coupling deformation of the flexible link are considered. Furthermore, the effects of the flexible joint are also considered in order to provide an important theoretical basis for the research of the vibration suppression and control of robots. The flexible joint is simplified as a linear torsion spring with damping, and the mass effect of the flexible joint is also considered in the model. Secondly, the dynamic simulations of the spatial manipulators are done to explore the effects of the joint stiffness and damping on the dynamic response of the robot system. The results show that as the stiffness coefficient increases, the amplitude of dynamic response of the flexible robot decreases, and the vibration frequency of the system becomes larger. As the damping coefficient increases, the dynamic response of the flexible robot decreases, and the dynamic response decays faster. The vibration of the flexible robot can be suppressed by adjusting the values of the stiffness and damping of the flexible joint. Finally, in order to study the effects of the flexibility of the joint on the control system, the rigid-joint manipulator and flexible-joint manipulator are made to move under the same circular motion. Then the joint torques of the two system are obtained respectively by solving the inverse dynamics equations, and the influence of the flexibility of the joint on the dynamics control is studied. The results show that the actuating torques required in the flexible-joint system are reduced compared to that required in the rigid-joint system.